Environment is not the Most Important Variable in Determining Oral Morphine Consumption in Wistar Rats

@article{Petrie1996EnvironmentIN,
  title={Environment is not the Most Important Variable in Determining Oral Morphine Consumption in Wistar Rats},
  author={Bruce Fraser Petrie},
  journal={Psychological Reports},
  year={1996},
  volume={78},
  pages={391 - 400}
}
  • B. Petrie
  • Published 1 April 1996
  • Psychology, Medicine
  • Psychological Reports
The role of differential housing on sucrose-morphine consumption in outbred Wistar rats was investigated in two studies. The results of earlier research, indicating rats housed in a quasinatural colony drank significantly less sucrose-morphine than rats isolated in standard laboratory cages, could not be replicated, as the consumption of sucrose-morphine by the isolated animals in the present two studies was reduced. It is possible that during a colony conversion the supplier inadvertently… Expand

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References

SHOWING 1-10 OF 23 REFERENCES
Effect of early and later colony housing on oral ingestion of morphine in rats
Male and female rats were raised from weaning either in isolation or in a large colony. At 65 days of age, half the rats in each environment were moved to the other. At 80 days, the animals wereExpand
Establishment of morphine preference in the rat
Three groups of rats were placed on sucrose morphine and milled rat food for 25 days. Morphine HCl content was.5 mg/ml for all three groups. Sucrose concentrations were 2.5%, 5%, and 10%. In aExpand
Addiction Liability of Albino Rats: Breeding for Quantitative Differences in Morphine Drinking
TLDR
Two strains of rats that differ in their susceptibility to morphine addiction are produced, and further selection and inbreeding increased the strain difference in the F2 and F3 generations. Expand
Voluntary morphine ingestion, morphine dependence, and recovery from withdrawal signs
TLDR
The present finding is the first report to show that rats ingest high quantities of sucrose-morphine without premedication or forced hydration procedures. Expand
Effects of chronic naltrexone on amphetamine locomotor activity.
TLDR
Chronic naltrexone significantly decreased amphetamine activity in old colony animals only under noise conditions, and new colony animals showed a significant attenuation in amphetamine locomotor activity in the absence of noise only. Expand
Within- and Between-Subjects Differences in the Effect of Morphine in Mice
TLDR
The between-subjects design was more sensitive than the within- subjects design in detecting morphine-induced locomotor and analgesic effects across four repeated injections of morphine. Expand
A drug dispenser to measure individual drinking in rat colonies
TLDR
An automated device which substantially facilitates the measurement of oral drug consumption by individual rats housed in a colony with a common drinking source is described. Expand
Heroin addiction and the role of methadone in its treatment.
  • A. Goldstein
  • Psychology, Medicine
  • Archives of general psychiatry
  • 1972
TLDR
A methamphetamineadone temporary support program is outlined, as an alternative to methadone maintenance of indefinite duration, to strengthen that motivation by providing a nonpunitive environment within which self-help and peer help can operate to alter life style. Expand
Heroin addiction. Sequential treatment employing pharmacologic supports.
  • A. Goldstein
  • Psychology, Medicine
  • Archives of general psychiatry
  • 1976
A system of treatment for heroin addiction is proposed under the acronym STEPS (sequential treatment employing pharmacologic supports). Small steps characterized by decreasing narcotic-inducedExpand
Strain differences in the response of rats to the injection of nickel sulphide.
  • M. Daniel
  • Medicine
  • British Journal of Cancer
  • 1966
TLDR
Images courtesy of AFP, AP, EPA, Getty Images and Reuters. Expand
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