Envelope glycoproteins of human immunodeficiency virus type 1 variants issued from mother-infant pairs display a wide spectrum of biological properties.

@article{Thenin2012EnvelopeGO,
  title={Envelope glycoproteins of human immunodeficiency virus type 1 variants issued from mother-infant pairs display a wide spectrum of biological properties.},
  author={Suzie Thenin and Tanawan Samleerat and E. P. Tavernier and Nicole Ngo-Giang-Huong and Gonzague Jourdain and Marc J Lallemant and Francis Barin and Martine Braibant},
  journal={Virology},
  year={2012},
  volume={426 1},
  pages={12-21}
}
Several studies have shown that the early virus population present in HIV-1 infected infants usually is homogeneous when compared to the highly diversified viral population present at delivery in their mothers. We explored the antigenic and functional properties of pseudotyped viruses expressing gp120 encoded by env clones issued from four mother-infant pairs infected by CRF01_AE viruses. We compared their sensitivity to neutralization and to entry inhibitors, their infectivity levels and the… CONTINUE READING