Envelope glycoprotein gp120 of human immunodeficiency virus type 1 alters ion transport in astrocytes: implications for AIDS dementia complex.

@article{Benos1994EnvelopeGG,
  title={Envelope glycoprotein gp120 of human immunodeficiency virus type 1 alters ion transport in astrocytes: implications for AIDS dementia complex.},
  author={Dale J. Benos and Beatrice H. Hahn and James K. Bubien and Salil K. Ghosh and Nicole A Mashburn and Margery A. Chaikin and George M. Shaw and Etty Nadia Benveniste},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 2},
  pages={494-8}
}
Infection by human immunodeficiency virus type 1 (HIV-1) is often complicated by a variety of neurological abnormalities. The most common clinical syndrome, termed acquired immunodeficiency syndrome (AIDS) dementia complex, presents as a subcortical dementia with cognitive, motor, and behavioral disturbances and is unique to HIV-1 infection. The pathogenesis of this syndrome is poorly understood but is believed to involve interactions among virally infected macrophages/microglia, astrocytes… CONTINUE READING

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Envelope glycoprotein gp120 of human immunodeficiency virus type 1 alters ion transport in astrocytes : implications for AIDS dementia complex .
Envelope glycoprotein gp120 of human immunodeficiency virus type 1 alters ion transport in astrocytes : implications for AIDS dementia complex .
As a result of modulation of astrocytic function by gp120 , the ensuing neuronal depolarization and glutamate exposure could activate both voltage - gated and N - methyl - D - aspartate - regulated Ca2 + channels , leading to increases in intraneuronal Ca2 + and neuronal death .
As a result of modulation of astrocytic function by gp120 , the ensuing neuronal depolarization and glutamate exposure could activate both voltage - gated and N - methyl - D - aspartate - regulated Ca2 + channels , leading to increases in intraneuronal Ca2 + and neuronal death .
Envelope glycoprotein gp120 of human immunodeficiency virus type 1 alters ion transport in astrocytes : implications for AIDS dementia complex .
HIV InfectionsIs associated disease ofAIDS Dementia Complex
Envelope glycoprotein gp120 of human immunodeficiency virus type 1 alters ion transport in astrocytes : implications for AIDS dementia complex .
Infection by human immunodeficiency virus type 1 ( HIV-1 ) is often complicated by a variety of neurological abnormalities .
Envelope glycoprotein gp120 of human immunodeficiency virus type 1 alters ion transport in astrocytes : implications for AIDS dementia complex .
PotassiumContraindicating class ofAmiloride
In this study , we show that exposure of primary rat and human astrocytes to heat - activated HIV-1 virions , or to eukaryotically expressed HIV-1 and HIV-2 envelope glycoproteins ( gp120 ) stimulates amiloride - sensitive Na+/H+ antiport , potassium conductance , and glutamate efflux .
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