Envelope-dependent, cyclophilin-independent effects of glycosaminoglycans on human immunodeficiency virus type 1 attachment and infection.

@article{Zhang2002EnvelopedependentCE,
  title={Envelope-dependent, cyclophilin-independent effects of glycosaminoglycans on human immunodeficiency virus type 1 attachment and infection.},
  author={Yi-jun Zhang and Theodora Hatziioannou and Trinity Zang and Douglas Braaten and Jeremy Luban and Stephen P Goff and Paul D Bieniasz},
  journal={Journal of virology},
  year={2002},
  volume={76 12},
  pages={6332-43}
}
Cell surface glycosaminoglycans (GAGs), in particular heparan sulfate (HS), have been proposed to mediate the attachment of human immunodeficiency virus type 1 (HIV-1) to target cells prior to virus entry, and both the viral gp120 envelope protein and virion-associated cyclophilin A (CypA) have been shown to directly interact with HS and its analogues. To determine the role of GAGs in HIV attachment and infection, we generated HIV-susceptible derivatives of CHO cell lines that either express… CONTINUE READING

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