Envelope-Constrained Neutralization-Sensitive HIV-1 After Heterosexual Transmission

  title={Envelope-Constrained Neutralization-Sensitive HIV-1 After Heterosexual Transmission},
  author={Cynthia A. Derdeyn and Julie M. Decker and Frédéric Bibollet-Ruche and John L Mokili and Mark T Muldoon and Scott A Denham and Marintha Heil and Francis Chisaka Kasolo and Rosemary Mubanga Musonda and Beatrice H. Hahn and George M. Shaw and Bette T. Korber and Susan A Allen and Eric Hunter},
  pages={2019 - 2022}
Heterosexual transmission accounts for the majority of human immunodeficiency virus–1 (HIV-1) infections worldwide, yet the viral properties that determine transmission fitness or outgrowth have not been elucidated. Here we show, for eight heterosexual transmission pairs, that recipient viruses were monophyletic, encoding compact, glycan-restricted envelope glycoproteins. These viruses were also uniquely sensitive to neutralization by antibody from the transmitting partner. Thus, the exposure… 

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