Enumeration of the simian virus 40 early region elements necessary for human cell transformation.

@article{Hahn2002EnumerationOT,
  title={Enumeration of the simian virus 40 early region elements necessary for human cell transformation.},
  author={William C. Hahn and Scott K. Dessain and Mary W. Brooks and Jessie E. King and Brian Elenbaas and David M. Sabatini and James A. DeCaprio and Robert A Weinberg},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 7},
  pages={2111-23}
}
While it is clear that cancer arises from the accumulation of genetic mutations that endow the malignant cell with the properties of uncontrolled growth and proliferation, the precise combinations of mutations that program human tumor cell growth remain unknown. The study of the transforming proteins derived from DNA tumor viruses in experimental models of transformation has provided fundamental insights into the process of cell transformation. We recently reported that coexpression of the… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS