Enumeration of the Simian Virus 40 Early Region Elements Necessary for Human Cell Transformation

@article{Hahn2002EnumerationOT,
  title={Enumeration of the Simian Virus 40 Early Region Elements Necessary for Human Cell Transformation},
  author={W. Hahn and S. Dessain and M. W. Brooks and J. King and B. Elenbaas and D. Sabatini and J. DeCaprio and R. Weinberg},
  journal={Molecular and Cellular Biology},
  year={2002},
  volume={22},
  pages={2111 - 2123}
}
  • W. Hahn, S. Dessain, +5 authors R. Weinberg
  • Published 2002
  • Medicine, Biology
  • Molecular and Cellular Biology
  • ABSTRACT While it is clear that cancer arises from the accumulation of genetic mutations that endow the malignant cell with the properties of uncontrolled growth and proliferation, the precise combinations of mutations that program human tumor cell growth remain unknown. The study of the transforming proteins derived from DNA tumor viruses in experimental models of transformation has provided fundamental insights into the process of cell transformation. We recently reported that coexpression of… CONTINUE READING
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