Enumeration of Smallest Intervention Strategies in Genome-Scale Metabolic Networks

@inproceedings{Kamp2014EnumerationOS,
  title={Enumeration of Smallest Intervention Strategies in Genome-Scale Metabolic Networks},
  author={Axel von Kamp and Steffen Klamt},
  booktitle={PLoS Computational Biology},
  year={2014}
}
One ultimate goal of metabolic network modeling is the rational redesign of biochemical networks to optimize the production of certain compounds by cellular systems. Although several constraint-based optimization techniques have been developed for this purpose, methods for systematic enumeration of intervention strategies in genome-scale metabolic networks are still lacking. In principle, Minimal Cut Sets (MCSs; inclusion-minimal combinations of reaction or gene deletions that lead to the… CONTINUE READING
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