Entry into S phase is inhibited in human fibroblasts by rat liver poly(A)+RNA.

Abstract

Initiation of DNA synthesis was inhibited in human fibroblasts following microinjection with poly(A)+RNA derived from normal rat liver. After sucrose gradient sedimentation of the RNA, the inhibitory activity was found to be limited to two adjacent fractions. Dilution experiments suggest a minimum abundance level of 0.015% for this mRNA(s). Studies on the… (More)

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