Entry inhibitors and their use in the treatment of HIV-1 infection.


Entry of HIV into target cells is a complex, multi-stage process involving sequential attachment and CD4 binding, coreceptor binding, and membrane fusion. HIV entry inhibitors are a complex group of drugs with multiple mechanisms of action depending on the stage of the viral entry process they target. Two entry inhibitors are currently approved for the… (More)
DOI: 10.1016/j.antiviral.2013.03.017