Entry inhibitor-based microbicides are active in vitro against HIV-1 isolates from multiple genetic subtypes.

@article{Ketas2007EntryIM,
  title={Entry inhibitor-based microbicides are active in vitro against HIV-1 isolates from multiple genetic subtypes.},
  author={Thomas J. Ketas and Susan M. Schader and Juan Antonio Rielo Zurita and Esther H. Teo and Victoria Polonis and Min Lu and Per Johan Klasse and John P. Moore},
  journal={Virology},
  year={2007},
  volume={364 2},
  pages={
          431-40
        }
}
Inhibitors of viral entry are under consideration as topical microbicides to prevent HIV-1 sexual transmission. Small molecules targeting HIV-1 gp120 (BMS-378806) or CCR5 (CMPD167), and a peptide fusion inhibitor (C52L), each blocks vaginal infection of macaques by a SHIV. A microbicide, however, must be active against multiple HIV-1 variants. We therefore tested BMS-C (a BMS-378806 derivative), CMPD167, C52L and the CXCR4 ligand AMD3465, alone and in combination, against 25 primary R5, 12 X4… CONTINUE READING
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