Entropy loss in long-distance DNA looping.

  title={Entropy loss in long-distance DNA looping.},
  author={Andreas Hanke and Ralf Metzler},
  journal={Biophysical journal},
  volume={85 1},
The entropy loss due to the formation of one or multiple loops in circular and linear DNA chains is calculated from a scaling approach in the limit of long chain segments. The analytical results allow us to obtain a fast estimate for the entropy loss for a given configuration. Numerical values obtained for some examples suggest that the entropy loss encountered in loop closure in typical genetic switches may become a relevant factor in comparison to both k(B)T and typical bond energies in… CONTINUE READING


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