Entropy in molecular recognition by proteins.

@article{Caro2017EntropyIM,
  title={Entropy in molecular recognition by proteins.},
  author={Jos{\'e} Alfredo Caro and Kyle William Harpole and Vignesh Kasinath and Jackwee Lim and Jeffrey Granja and Kathleen Gentilcore Valentine and Kim A. Sharp and A Joshua Wand},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2017},
  volume={114 25},
  pages={
          6563-6568
        }
}
Molecular recognition by proteins is fundamental to molecular biology. Dissection of the thermodynamic energy terms governing protein-ligand interactions has proven difficult, with determination of entropic contributions being particularly elusive. NMR relaxation measurements have suggested that changes in protein conformational entropy can be quantitatively obtained through a dynamical proxy, but the generality of this relationship has not been shown. Twenty-eight protein-ligand complexes are… CONTINUE READING
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