Entropy in biological binding processes: estimation of translational entropy loss.

@article{Murphy1994EntropyIB,
  title={Entropy in biological binding processes: estimation of translational entropy loss.},
  author={Kenneth P. Murphy and Daiqian Xie and Katherine Jenny Thompson and L. Mario Amzel and Ernesto Freire},
  journal={Proteins},
  year={1994},
  volume={18 1},
  pages={63-7}
}
The loss of translational degrees of freedom makes an important, unfavorable contribution to the free energy of binding. Examination of experimental values suggest that calculation of this entropy using the Sackur-Tetrode equation produces largely overestimated values. Better agreement is obtained using the cratic entropy. Theoretical considerations suggest… CONTINUE READING