Entropy as the driver of chromosome segregation

  title={Entropy as the driver of chromosome segregation},
  author={Suckjoon Jun and Andrew Wright},
  journal={Nature Reviews Microbiology},
We present a new physical biology approach to understanding the relationship between the organization and segregation of bacterial chromosomes. We posit that replicated Escherichia coli daughter strands will spontaneously demix as a result of entropic forces, despite their strong confinement within the cell; in other words, we propose that entropy can act as a primordial physical force which drives chromosome segregation under the right physical conditions. Furthermore, proteins implicated in… CONTINUE READING
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