Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences

@article{Barcel2007EntropicallydrivenBO,
  title={Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences},
  author={F. Barcel{\'o} and C. Scotta and M. Ortiz-Lombardía and C. M{\'e}ndez and J. Salas and J. Portugal},
  journal={Nucleic Acids Research},
  year={2007},
  volume={35},
  pages={2215 - 2226}
}
The antitumour antibiotic mithramycin A (MTA) is a DNA minor-groove binding ligand. It binds to C/G-rich tracts as a dimer that forms in the presence of divalent cations such as Mg2+. Differential scanning calorimetry, UV thermal denaturation, isothermal titration calorimetry and competition dialysis were used, together with computations of the hydrophobic free energy of binding, to determine the thermodynamic profile of MTA binding to DNA. The results were compared to those obtained in… Expand
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