Entropic organization of interphase chromosomes

  title={Entropic organization of interphase chromosomes},
  author={Peter R. Cook and Davide Marenduzzo},
  booktitle={The Journal of cell biology},
Chromosomes are not distributed randomly in nuclei. Appropriate positioning can activate (or repress) genes by bringing them closer to active (or inactive) compartments like euchromatin (or heterochromatin), and this is usually assumed to be driven by specific local forces (e.g., involving H bonds between nucleosomes or between nucleosomes and the lamina). Using Monte Carlo simulations, we demonstrate that nonspecific (entropic) forces acting alone are sufficient to position and shape self… CONTINUE READING
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