Entrapment of purified alpha-hemoglobin chains in normal erythrocytes as a model for human beta thalassemia.

  • Matthew D Scott
  • Published 1992 in Advances in experimental medicine and biology

Abstract

Entrapment of purified alpha-hemoglobin chains within normal erythrocytes resulted in structural and functional changes very similar to those observed in human beta thalassemic erythrocytes (Table 1). Membrane proteins and reactive thiol groups were decreased in a pattern similar to that observed in vivo in beta thalassemia. In addition, the alpha-chain… (More)

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