Entrapment of intracytosolic bacteria by septin cage-like structures.

@article{Mostowy2010EntrapmentOI,
  title={Entrapment of intracytosolic bacteria by septin cage-like structures.},
  author={Serge Mostowy and Matteo Bonazzi and M{\'e}lanie Anne Hamon and To Nam Tham and Adeline Mallet and Micka{\"e}l Lelek and Edith Gouin and Caroline Demangel and Roland Brosch and Christophe Zimmer and Anna Sartori and Makoto Kinoshita and Marc Lecuit and Pascale Cossart},
  journal={Cell host & microbe},
  year={2010},
  volume={8 5},
  pages={
          433-44
        }
}

• Serge Mostowy, Matteo Bonazzi, +11 authors Pascale Cossart
• Published in Cell host & microbe 2010
• DOI:10.1016/j.chom.2010.10.009

Actin-based motility is used by various pathogens for dissemination within and between cells. Yet host factors restricting this process have not been identified. Septins are GTP-binding proteins that assemble as filaments and are essential for cell division. However, their role during interphase has remained elusive. Here, we report that septin assemblies are recruited to different bacteria that polymerize actin. We observed that intracytosolic Shigella either become compartmentalized in septin… CONTINUE READING

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