Entrance in mitosis of adult cardiomyocytes in ischemic pig hearts after plasmid-mediated rhVEGF165 gene transfer

@article{Laguens2002EntranceIM,
  title={Entrance in mitosis of adult cardiomyocytes in ischemic pig hearts after plasmid-mediated rhVEGF165 gene transfer},
  author={R. Laguens and P. Meckert and G. V. Janavel and H. D. Valle and E. Lascano and J. Negroni and P. Werba and L. Cuniberti and V. Mart{\'i}nez and C. Melo and M. Papouchado and R. Ojeda and M. Criscuolo and A. Crottogini},
  journal={Gene Therapy},
  year={2002},
  volume={9},
  pages={1676-1681}
}
Replacement of the cell loss occurring after acute myocardial infarction has been proposed as a potential treatment to prevent heart remodeling and failure. On account that cardiomyocytes express VEGF receptors and that VEGF triggers mitogen-activated protein kinases, we investigated if VEGF gene transfer may induce cardiomyocyte replication. In a pig model of chronic myocardial ischemia achieved by Ameroid occlusion of the left circumflex coronary artery, we observed that direct… Expand
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