Entorhinal cortex of aged subjects with Down’s syndrome shows severe neuronal loss caused by neurofibrillary pathology

@article{Sadowski1999EntorhinalCO,
  title={Entorhinal cortex of aged subjects with Down’s syndrome shows severe neuronal loss caused by neurofibrillary pathology},
  author={Marcin Sadowski and Henryk M. Wiśniewski and Michal Tarnawski and Piotr Kozlowski and Boleslaw Lach and Jerzy Wegiel},
  journal={Acta Neuropathologica},
  year={1999},
  volume={97},
  pages={156-164}
}
In Alzheimer’s disease (AD), neurofibrillary degeneration of neurons starts in the transentorhinal cortex and spreads in a time-dependent manner to the entorhinal cortex, which provides a major input to the hippocampus – a key structure of the memory system. People with Down’s syndrome (DS) develop neurofibrillary changes more than 30 years earlier than those with sporadic AD. To characterize AD-related pathology in the entorhinal cortex in DS, we examined seven subjects with DS of 60–74 years… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 78 references

Similar Papers

Loading similar papers…