Entorhinal Principal Neurons Mediate Brain-stimulation Treatments for Epilepsy


Brain stimulation is an alternative treatment for epilepsy. However, the neuronal circuits underlying its mechanisms remain obscure. We found that optogenetic activation (1Hz) of entorhinal calcium/calmodulin-dependent protein kinase II α (CaMKIIα)-positive neurons, but not GABAergic neurons, retarded hippocampal epileptogenesis and reduced hippocampal… (More)
DOI: 10.1016/j.ebiom.2016.11.027


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