Entorhinal Principal Neurons Mediate Brain-stimulation Treatments for Epilepsy

Abstract

Brain stimulation is an alternative treatment for epilepsy. However, the neuronal circuits underlying its mechanisms remain obscure. We found that optogenetic activation (1Hz) of entorhinal calcium/calmodulin-dependent protein kinase II α (CaMKIIα)-positive neurons, but not GABAergic neurons, retarded hippocampal epileptogenesis and reduced hippocampal… (More)
DOI: 10.1016/j.ebiom.2016.11.027

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