• DOI:10.1016/0167-4838(87)90154-3
Corpus ID: 2112637

Enthalpy and entropy of hippuraldehyde hydration and binding to papain.

@article{Moon1987EnthalpyAE,
  title={Enthalpy and entropy of hippuraldehyde hydration and binding to papain.},
  author={J. Moon and R. Hanzlik},
  journal={Biochimica et biophysica acta},
  year={1987},
  volume={914 1},
  pages={
          1-5
        }
}

J. Moon, R. Hanzlik

Published 1987

Chemistry, Medicine

Biochimica et biophysica acta

In aqueous solution hippuraldehyde, PhCONHCH2CHO, is approx. 10-times more extensively hydrated than simple aliphatic aldehydes. Studies of the temperature dependence of the NMR spectrum of hippuraldehyde and its hydrate in 2H2O indicate that the dehydration is endothermic (delta H = 3.9 +/- 0.9 kcal/mol), but entropically favored (delta S = 7.9 +/- 1.9 cal/mol per deg). For simple aliphatic aldehydes the corresponding dehydration is slightly more endothermic, but somewhat more favorable… CONTINUE READING

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