Enterovirus D-68 Infection, Prophylaxis, and Vaccination in a Novel Permissive Animal Model, the Cotton Rat (Sigmodon hispidus)

@inproceedings{Patel2016EnterovirusDI,
  title={Enterovirus D-68 Infection, Prophylaxis, and Vaccination in a Novel Permissive Animal Model, the Cotton Rat (Sigmodon hispidus)},
  author={Mira C. Patel and Wei Wang and Lioubov M. Pletneva and Seesandra V. Rajagopala and Yi Tan and Tina V Hartert and Marina S. Boukhvalova and Stefanie N. Vogel and Suman R Das and Jorge C G Blanco},
  booktitle={PloS one},
  year={2016}
}
In recent years, there has been a significant increase in detection of Enterovirus D-68 (EV-D68) among patients with severe respiratory infections worldwide. EV-D68 is now recognized as a re-emerging pathogen; however, due to lack of a permissive animal model for EV-D68, a comprehensive understanding of the pathogenesis and immune response against EV-D68 has been hampered. Recently, it was shown that EV-D68 has a strong affinity for α2,6-linked sialic acids (SAs) and we have shown previously… CONTINUE READING
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