Enterotoxigenic Escherichia coli prevents host NF-κB activation by targeting IκBα polyubiquitination.

@article{Wang2012EnterotoxigenicEC,
  title={Enterotoxigenic Escherichia coli prevents host NF-κB activation by targeting IκBα polyubiquitination.},
  author={Xiaogang Wang and Philip R Hardwidge},
  journal={Infection and immunity},
  year={2012},
  volume={80 12},
  pages={4417-25}
}
The NF-κB pathway regulates innate immune responses to infection. NF-κB is activated after pathogen-associated molecular patterns are detected, leading to the induction of proinflammatory host responses. As a countermeasure, bacterial pathogens have evolved mechanisms to subvert NF-κB signaling. Enterotoxigenic Escherichia coli (ETEC) causes diarrheal disease and significant morbidity and mortality for humans in developing nations. The extent to which this important pathogen subverts innate… CONTINUE READING
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