Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health.

@article{Koch2017EnterosalivaryNM,
  title={Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health.},
  author={Carl D Koch and Mark T Gladwin and Bruce A. Freeman and Jon O N Lundberg and Eddie Weitzberg and Alison M Morris},
  journal={Free radical biology & medicine},
  year={2017},
  volume={105},
  pages={48-67}
}
Recent insights into the bioactivation and signaling actions of inorganic, dietary nitrate and nitrite now suggest a critical role for the microbiome in the development of cardiac and pulmonary vascular diseases. Once thought to be the inert, end-products of endothelial-derived nitric oxide (NO) heme-oxidation, nitrate and nitrite are now considered major sources of exogenous NO that exhibit enhanced vasoactive signaling activity under conditions of hypoxia and stress. The bioavailability of… CONTINUE READING
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