Enterokinase, the initiator of intestinal digestion, is a mosaic protease composed of a distinctive assortment of domains.

@article{Kitamoto1994EnterokinaseTI,
  title={Enterokinase, the initiator of intestinal digestion, is a mosaic protease composed of a distinctive assortment of domains.},
  author={Yasunori Kitamoto and Xianlong Yuan and Qingyu Wu and David McCourt and J Evan Sadler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 16},
  pages={
          7588-92
        }
}
Enterokinase is a protease of the intestinal brush border that specifically cleaves the acidic propeptide from trypsinogen to yield active trypsin. This cleavage initiates a cascade of proteolytic reactions leading to the activation of many pancreatic zymogens. The full-length cDNA sequence for bovine enterokinase and partial cDNA sequence for human enterokinase were determined. The deduced amino acid sequences indicate that active two-chain enterokinase is derived from a single-chain precursor… CONTINUE READING
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