Enterohepatic cycling of bilirubin as a cause of 'black' pigment gallstones in adult life.

@article{Vtek2003EnterohepaticCO,
  title={Enterohepatic cycling of bilirubin as a cause of 'black' pigment gallstones in adult life.},
  author={Libor V{\'i}tek and Martin C. Carey},
  journal={European journal of clinical investigation},
  year={2003},
  volume={33 9},
  pages={
          799-810
        }
}
In contrast to bile salts, which undergo a highly efficient enterohepatic circulation with multiple regulatory and physiologic functions, glucuronic acid conjugates of bilirubin are biliary excretory molecules that in health do not have a continuing biologic life. Intestinal absorptive cells are devoid of recapture transporters for bilirubin conjugates, and their large size and polarity prevent absorption by passive diffusion. However, unconjugated bilirubin, the beta-glucuronidase hydrolysis… CONTINUE READING
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