Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein.

@article{Kok2003EnterohepaticCO,
  title={Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein.},
  author={Tineke Kok and Christian Victor Hulzebos and H. -J. Wolters and Rick Havinga and Luis B. Agellon and Frans Stellaard and Bei Shan and Margrit Schwarz and Folkert Kuipers},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 43},
  pages={41930-7}
}
The bile salt-activated farnesoid X receptor (FXR; NR1H4) controls expression of several genes considered crucial in maintenance of bile salt homeostasis. We evaluated the physiological consequences of FXR deficiency on bile formation and on the kinetics of the enterohepatic circulation of cholate, the major bile salt species in mice. The pool size, fractional turnover rate, synthesis rate, and intestinal absorption of cholate were determined by stable isotope dilution and were related to… CONTINUE READING

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