Enterohepatic Disposition of Rosuvastatin in Pigs and the Impact of Concomitant Dosing with Cyclosporine and Gemfibrozil

@article{Bergman2009EnterohepaticDO,
  title={Enterohepatic Disposition of Rosuvastatin in Pigs and the Impact of Concomitant Dosing with Cyclosporine and Gemfibrozil},
  author={E. Bergman and A. Lundahl and Patrik Fridblom and M. Hedeland and U. Bondesson and L. Knutson and H. Lennern{\"a}s},
  journal={Drug Metabolism and Disposition},
  year={2009},
  volume={37},
  pages={2349 - 2358}
}
  • E. Bergman, A. Lundahl, +4 authors H. Lennernäs
  • Published 2009
  • Chemistry, Medicine
  • Drug Metabolism and Disposition
  • The hepatobiliary transport and local disposition of rosuvastatin in pig were investigated, along with the impact of concomitant dosing with two known multiple transport inhibitors; cyclosporine and gemfibrozil. Rosuvastatin (80 mg) was administered as an intrajejunal bolus dose in treatments I, II, and III (TI, TII, and TIII, respectively; n = 6 per treatment). Cyclosporine (300 mg) and gemfibrozil (600 mg) were administered in addition to the rosuvastatin dose in TII and TIII, respectively… CONTINUE READING
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