Enterohemorrhagic and enteropathogenic Escherichia coli evolved different strategies to resist antimicrobial peptides.

@article{Thomassin2012EnterohemorrhagicAE,
  title={Enterohemorrhagic and enteropathogenic Escherichia coli evolved different strategies to resist antimicrobial peptides.},
  author={Jenny-Lee Thomassin and John R. Brannon and Julienne C Kaiser and Samantha Gruenheid and Herv{\'e} Le Moual},
  journal={Gut microbes},
  year={2012},
  volume={3 6},
  pages={556-61}
}
Enterohemorrhagic and enteropathogenic Escherichia coli (EHEC and EPEC) are enteric human pathogens that colonize the large and small intestines, respectively. To establish infection EHEC and EPEC must overcome innate host defenses, such as antimicrobial peptides (AMPs) produced by the intestinal epithelium. Gram-negative pathogens have evolved different mechanisms to resist AMPs, including outer-membrane proteases that degrade AMPs. We showed that the protease OmpT degrades the human AMP LL-37… CONTINUE READING
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