Enterodiol and enterolactone modulate the immune response by acting on nuclear factor-kappaB (NF-kappaB) signaling.

@article{Corsini2010EnterodiolAE,
  title={Enterodiol and enterolactone modulate the immune response by acting on nuclear factor-kappaB (NF-kappaB) signaling.},
  author={Emanuela Corsini and Mario Dell'Agli and Alessandra Facchi and Emma De Fabiani and Laura Lucchi and Maria Serena Boraso and Marina Marinovich and Corrado Lodovico Galli},
  journal={Journal of agricultural and food chemistry},
  year={2010},
  volume={58 11},
  pages={6678-84}
}
Lignan-rich whole-grain cereals, beans, berries, and nuts show protective effects against a variety of chronic diseases, including cancer. Lignans are converted by intestinal microflora to enterolactone (EL) and its oxidation product enterodiol (ED). To investigate the immunomodulatory effect of EL and ED in human cells, peripheral blood lymphocytes were treated with increasing physiologically relevant concentrations of EL and ED (0-1000 microM) and stimulated with lipopolysaccharide (LPS) and… CONTINUE READING

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