Enterodiol and enterolactone, two major diet-derived polyphenol metabolites have different impact on ERalpha transcriptional activation in human breast cancer cells.

@article{Carreau2008EnterodiolAE,
  title={Enterodiol and enterolactone, two major diet-derived polyphenol metabolites have different impact on ERalpha transcriptional activation in human breast cancer cells.},
  author={Charlotte Carreau and Gilles Flouriot and Catherine Bennetau-Pelissero and Myl{\`e}ne Potier},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={2008},
  volume={110 1-2},
  pages={176-85}
}
Lignans are plant compounds metabolized in the mammalian gut to produce the estrogenic enterolignans, enterodiol (ED) and enterolactone (EL). Because estrogens have been linked to breast cancer etiology, enterolignans could affect breast cancer risk, but to our knowledge, the mechanisms by which they exert their estrogenic and/or anti-estrogenic effects in humans are still unclear. To better understand how estrogenic compounds from the food, such as the enterolignans, might influence breast… CONTINUE READING
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