Enterocyte-like differentiation of the Caco-2 intestinal cell line is associated with increases in AP-1 protein binding.

The nuclear factor AP-1, a large family of transcription factors composed of the Jun and Fos protein families, plays a role in the differentiation of various cells; the role of the AP-1 factors in intestinal differentiation is not known. Members of the AP-1 family can be activated by the Ras pathway and, in addition, Ras appears to be important for gut… CONTINUE READING