Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation

@inproceedings{Gilbert2012EnterocyteSP,
  title={Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation},
  author={Shila Gilbert and Rongli Zhang and Lee A. Denson and Richard Moriggl and Kris A. Steinbrecher and Noah F Shroyer and James Lin and Xiaonan Han},
  booktitle={EMBO molecular medicine},
  year={2012}
}
Epithelial myosin light chain kinase (MLCK)-dependent barrier dysfunction contributes to the pathogenesis of inflammatory bowel diseases (IBD). We reported that epithelial GM-CSF-STAT5 signalling is essential for intestinal homeostatic response to gut injury. However, mechanism, redundancy by STAT5 or cell types involved remained foggy. We here generated intestinal epithelial cell (IEC)-specific STAT5 knockout mice, these mice exhibited a delayed mucosal wound healing and dysfunctional… CONTINUE READING