Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4.

Abstract

PURPOSE Cytotoxic T-lymphocyte-associated antigen 4 (CTLA4) is an inhibitory receptor on T cells. Knocking out CTLA4 in mice causes lethal lymphoproliferation, and polymorphisms in human CTLA4 are associated with autoimmune disease. Trials of the anti-CTLA4 antibody ipilimumab (MDX-010) have resulted in durable cancer regression and immune-mediated… (More)

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@article{Beck2006EnterocolitisIP, title={Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4.}, author={Kimberly E Beck and Joseph A. Blansfield and Khoi Q. Tran and Andrew L. Feldman and Marybeth S. Hughes and Richard E. Royal and Udai S. Kammula and Suzanne Louise Topalian and Richard M. Sherry and David Kleiner and Martha Quezado and Israel Lowy and Michael Jay Yellin and S. Rosenberg and James C Yang}, journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology}, year={2006}, volume={24 15}, pages={2283-9} }