Enterococcus faecalis induces aneuploidy and tetraploidy in colonic epithelial cells through a bystander effect.

@article{Wang2008EnterococcusFI,
  title={Enterococcus faecalis induces aneuploidy and tetraploidy in colonic epithelial cells through a bystander effect.},
  author={X Wang and Toby D Allen and Randal J May and Stanley A. Lightfoot and Courtney W. Houchen and Mark M. Huycke},
  journal={Cancer research},
  year={2008},
  volume={68 23},
  pages={9909-17}
}
Intestinal commensals are potential important contributors to the etiology of sporadic colorectal cancer, but mechanisms by which bacteria can initiate tumors remain uncertain. Herein, we describe mechanisms that link Enterococcus faecalis, a bacterium known to produce extracellular superoxide, to the acute induction of chromosomal instability. Immortalized human and nontransformed murine colonic epithelial cells, along with a mouse colonic ligation model, were used to assess the effect of E… CONTINUE READING
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