Enterococcus faecalis pCF10-encoded surface proteins PrgA, PrgB (aggregation substance) and PrgC contribute to plasmid transfer, biofilm formation and virulence.

@article{Bhatty2015EnterococcusFP,
  title={Enterococcus faecalis pCF10-encoded surface proteins PrgA, PrgB (aggregation substance) and PrgC contribute to plasmid transfer, biofilm formation and virulence.},
  author={Minny Bhatty and Melissa R. Cruz and Kristi L Frank and Jenny A Laverde Gomez and Fernando Andrade and Danielle A. Garsin and Gary M Dunny and Heidi B. Kaplan and Peter J Christie},
  journal={Molecular microbiology},
  year={2015},
  volume={95 4},
  pages={660-77}
}
Enterococcus faecalis pCF10 transfers at high frequencies upon pheromone induction of the prgQ transfer operon. This operon codes for three cell wall-anchored proteins - PrgA, PrgB (aggregation substance) and PrgC - and a type IV secretion system through which the plasmid is delivered to recipient cells. Here, we defined the contributions of the Prg surface proteins to plasmid transfer, biofilm formation and virulence using the Caenorhabditis elegans infection model. We report that a… CONTINUE READING
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