Enteric neuronal ablation: structure-activity relationship in a series of alkyldimethylbenzylammonium chlorides.

Abstract

Serosal application of a commercial solution of benzalkonium chloride (BAC) has been shown to selectively ablate myenteric neurons in the rat jejunum. This experimental model has proven useful in the study of the role of the myenteric plexus in intestinal function. The commercial BAC is a mixture of at least three homologous N-alkyldimethylbenzylammonium… (More)

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