Enteric microflora contribute to constitutive ICAM-1 expression on vascular endothelial cells.

@article{Komatsu2000EntericMC,
  title={Enteric microflora contribute to constitutive ICAM-1 expression on vascular endothelial cells.},
  author={S. Komatsu and R. D. Berg and J. Russell and Y. Nimura and D. Granger},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2000},
  volume={279 1},
  pages={
          G186-91
        }
}
Quantitative estimates of endothelial cell adhesion molecule expression have revealed that some adhesion molecules [e.g., intercellular adhesion molecule-1 (ICAM-1)] are abundantly expressed in different vascular beds under normal conditions. The objective of this study was to determine whether the enteric microflora contribute to the constitutive expression of ICAM-1 and other endothelial cell adhesion molecules in the gastrointestinal tract and other regional vascular beds. The dual… Expand
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References

SHOWING 1-10 OF 49 REFERENCES
Quantification of murine endothelial cell adhesion molecules in solid tumors.
TLDR
It is suggested that the presence of a solid tumor does not influence endothelial CAM expression in other vascular beds and that the higher density of selectins in nonstimulated tumor vessels may promote the recruitment of rolling leukocytes in this tissue. Expand
Effects of intestinal stasis on intercellular adhesion molecule 1 expression in the rat: role of enteric bacteria.
TLDR
It is indicated that intestinal stasis is associated with an increased expression of ICAM-1 and granulocyte infiltration, which may be mediated by enteric bacteria. Expand
Cytokine-induced VCAM-1 and ICAM-1 expression in different organs of the mouse.
TLDR
These studies indicate that while there are significant quantitative differences in constitutive and induced expression of murine ICAM-1 and VCam-1, the kinetics and dose-response characteristics of the two adhesion molecules to TNF-alpha are qualitatively similar. Expand
Differential up-regulation of circulating soluble and endothelial cell intercellular adhesion molecule-1 in mice.
TLDR
Findings indicate that plasma sICAM-1 concentration does not accurately reflect the level of ICAM- 1 expression on endothelial cells in different vascular beds. Expand
Effects of chronic arterial hypertension on constitutive and induced intercellular adhesion molecule-1 expression in vivo.
TLDR
The results suggest that chronic arterial hypertension results in altered ICAM-1 expression on the endothelium, which may contribute to the abnormal inflammatory responses associated with this disease. Expand
Leukocyte-endothelial cell interactions: molecular mechanisms and implications in gastrointestinal disease.
TLDR
The different families of relevant adhesion molecules that participate in the coordinated recruitment of leukocytes into inflamed tissue are described and then discussed in terms of the pathophysiological alterations observed in selected experimental models of gastrointestinal disease. Expand
A VCAM-like adhesion molecule on murine bone marrow stromal cells mediates binding of lymphocyte precursors in culture
TLDR
The observations suggest that the murine and human cell adhesion proteins may be related, as the antibodies selectively interfered with B lymphocyte formation when included in long term bone marrow cultures and caused rapid detachment of lymphocytes from the adherent layer when added to preestablished cultures. Expand
Regional differences in constitutive and induced ICAM-1 expression in vivo.
TLDR
It is indicated that ICAM-1 is constitutively expressed on vascular endothelium in all organs of the rat and that there are significant regional differences in the magnitude and time course of endotoxin-induced ICAM -1 expression. Expand
Constitutive expression of ICAM-1 in rat microvascular systems analyzed by laser confocal microscopy.
TLDR
Results suggest that postcapillary venules serve as an active gateway with the readiness to help adhere circulating leukocytes exposed to proinflammatory stimuli in acute inflammation. Expand
Expression of mucosal addressin cell adhesion molecule‐1 (MAdCAM‐1) in acute and chronic inflammation
TLDR
It is demonstrated that TNF‐α enhances surface expression of MAdCAM‐1 in intestinal and colonic tissues to the same extent in both wild‐type and IL‐10 k/o mice with no colonic inflammation. Expand
...
1
2
3
4
5
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