Enteric glia

@article{Gershon1991EntericG,
  title={Enteric glia},
  author={Michael D. Gershon and Taube P. Rothman},
  journal={Glia},
  year={1991},
  volume={4}
}
The structure of the enteric nervous system (ENS) is different from that of extraenteric peripheral nerve. Collagen is excluded from the enteric plexuses and support for neuronal elements is provided by astrocyte‐like enteric glial cells. Enteric glia differ from Schwann cells in that they do not form basal laminae and they ensheath axons, not individually, but in groups. Although enteric glia are rich in the S‐100 and glial fibrillary acidic proteins, it has been difficult to find a single… 
Enteric glia
  • A. Rühl, Y. Nasser, K. Sharkey
  • Biology
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2004
TLDR
Enteric glia may serve as a link between the nervous and immune systems of the gut and may also have an important role in maintaining the integrity of the mucosal barrier and in other aspects of intestinal homeostasis.
Novel functional roles for enteric glia in the gastrointestinal tract
TLDR
The current body of evidence supporting functional roles of enteric glia is discussed and key gaps in the understanding of the physiology of these unique cells are identified.
Imaging neuron-glia interactions in the enteric nervous system
TLDR
A number of approaches to unravel the complex neuron-glia crosstalk in the ENS are described, focusing on the challenges and possibilities of live microscopic imaging in both animal models and human tissue samples.
Glial cells in the gut
  • A. Rühl
  • Biology
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2005
TLDR
Based on the available evidence, it is predictable that enteric glia are involved in the etiopathogenesis of various pathological processes in the gut, particularly such with neuroinflammatory or neurodegenerative components.
“Enteric glia as a source of neural progenitors in adult zebrafish”
TLDR
This work demonstrates that the non-neuronal ENS cell compartment of teleosts shares molecular and morphological characteristics with mammalian enteric glia but cannot be identified by the expression of canonical glia markers.
Heterogeneity and phenotypic plasticity of glial cells in the mammalian enteric nervous system
TLDR
These studies reveal extensive heterogeneity and phenotypic plasticity of enteric glial cells and set a framework for further investigations aimed at deciphering their role in digestive function and disease.
Enteric Glia: S100, GFAP, and Beyond
TLDR
The EGC population is species specific and as complex as CNS glia, and heterogeneity in morphology, localization, and transcription as well as interaction with surrounding cells indicate versatile functional properties of these cells for gut function in health and disease.
Enteric glia express proteolipid protein 1 and are a transcriptionally unique population of glia in the mammalian nervous system
TLDR
Enteric glia are transcriptionally unique and distinct from other cell types in the nervous system, suggesting that a combinatorial code of molecular markers can be used to identify distinct subtypes.
Role of enteric glial cells in inflammatory bowel disease
TLDR
Disruption of the EGC network in Crohn's disease patients may represent one possible cause for the enhanced mucosal permeability state and vascular dysfunction that are thought to favor mucosal inflammation.
Cellular development of the enteric nervous system in the chick embryo.
TLDR
The chemical and structural development of enteric plexuses was studied in the chick from embryonic day 4 to hatching and the presence of apoptotic cells in enteric ganglia, was studied using the TUNEL method and electron microscopy, suggesting that cell death contributes little, if at all, to the morphogenesis of the chick entericplexuses.
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