Enteric descending and afferent neural signaling stimulated by giant migrating contractions: essential contributing factors to visceral pain.

@article{Sarna2007EntericDA,
  title={Enteric descending and afferent neural signaling stimulated by giant migrating contractions: essential contributing factors to visceral pain.},
  author={S K Sarna},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2007},
  volume={292 2},
  pages={G572-81}
}
  • S K Sarna
  • Published 2007 in
    American journal of physiology. Gastrointestinal…
We investigated whether strong compression of an intestinal segment by giant migrating contractions (GMCs) initiates pseudoaffective signals from the gut, similar to those initiated by its distension with a balloon. The experiments were performed on conscious dogs by using close intra-arterial infusions of test substances that affect the receptors only in the infused segment. The stimulation of GMCs by close intra-arterial infusion of CGRP or distension of an intestinal segment by balloon… CONTINUE READING

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