Enteric defensins are essential regulators of intestinal microbial ecology

@inproceedings{Salzman2010EntericDA,
  title={Enteric defensins are essential regulators of intestinal microbial ecology},
  author={Nita H. Salzman and Kuiechun Hung and Dipica Haribhai and Hiutung Chu and Jenny Karlsson-Sj{\"o}berg and Elad Amir and Paul Teggatz and Melissa Barman and Michael D. Hayward and Daniel C. Eastwood and Maaike Stoel and Yanjiao Zhou and Erica Sodergren and George Weinstock and Charles L Bevins and Calvin B. Williams and Nicolaas A. Bos},
  booktitle={Nature Immunology},
  year={2010}
}
Antimicrobial peptides are important effectors of innate immunity throughout the plant and animal kingdoms. In the mammalian small intestine, Paneth cell α-defensins are antimicrobial peptides that contribute to host defense against enteric pathogens. To determine if α-defensins also govern intestinal microbial ecology, we analyzed the intestinal microbiota of mice expressing a human α-defensin gene (DEFA5) and in mice lacking an enzyme required for the processing of mouse α-defensins. In these… CONTINUE READING
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