Enteric adenovirus 41 (Tak) requires low serum for growth in human primary cells.

@article{Pieniazek1990EntericA4,
  title={Enteric adenovirus 41 (Tak) requires low serum for growth in human primary cells.},
  author={D Pieniazek and Norman J. Pienią{\vz}ek and Dennis G. Macejak and Ronald B. Luftig},
  journal={Virology},
  year={1990},
  volume={178 1},
  pages={72-80}
}
It had been postulated that due to lack of growth of enteric adenovirus 41 (Ad41) on human primary cells and its growth on Graham-293 cells there was a defect in the Ad41 E1A region. However, we found as a result of careful evaluation of Ad41 growth on several primary cell lines (HEK, WI-38, or Detroit 551) that efficient viral multiplication is possible if the serum concentration in the medium used postinfection (p.i.) is kept between 0.2 and 1%. In contrast, only slight growth of Ad41 occurs… CONTINUE READING