Enteric Nervous System Regulation of Intestinal Stem Cell Differentiation and Epithelial Monolayer Function

@inproceedings{Puzan2018EntericNS,
  title={Enteric Nervous System Regulation of Intestinal Stem Cell Differentiation and Epithelial Monolayer Function},
  author={Marissa Puzan and Sanjin Hosic and Caroline Ghio and Abigail N Koppes},
  booktitle={Scientific Reports},
  year={2018}
}
The Enteric Nervous System (ENS) is a complex network of neurons and glia, which regulates sensorimotor function throughout the gastroinestinal tract (GI). Here we investigated the role of the ENS and intestinal myofibroblasts in the maintenance of a primary intestinal epithelial barrier through regulation of monolayer permeability, cytokine production, and differentiation of intestinal stem cells. Utilizing a novel, in vitro, transwell-based coculture system, murine small intestinal stem cells… CONTINUE READING
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