Enteral feeding for very low birth weight infants: reducing the risk of necrotising enterocolitis

@article{Chauhan2007EnteralFF,
  title={Enteral feeding for very low birth weight infants: reducing the risk of necrotising enterocolitis},
  author={M Chauhan and Ginny Henderson and William McGuire},
  journal={Archives of Disease in Childhood Fetal and Neonatal Edition},
  year={2007},
  volume={93},
  pages={F162 - F166}
}
The principal modifiable risk factors for necrotising enterocolitis (NEC) in very low birth weight infants relate to enteral feeding practices. Evidence exists that feeding with formula milk increases the risk of NEC. Currently, only limited data are available on the effect of the timing of feed introduction and advancement on the risk of developing NEC. Large, multicentre randomised controlled trials of these strategies are needed. Other promising interventions that merit further evaluation… 
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References

SHOWING 1-10 OF 78 REFERENCES
The fear of necrotizing enterocolitis versus achieving optimal growth in preterm infants—an opinion
TLDR
Current evidence suggests significant benefits of enteral feeding that is started early and advanced at rates of 20–35 ml/kg/d.
Prolonging small feeding volumes early in life decreases the incidence of necrotizing enterocolitis in very low birth weight infants.
TLDR
Advancing feeding volumes increase the risk of NEC without providing benefits for motor function or feeding tolerance, neonatologists should consider using minimal feeding volumes until future trials assess the safety of advancing feeding volumes.
Rapid versus slow rate of advancement of feedings for promoting growth and preventing necrotizing enterocolitis in parenterally fed low-birth-weight infants.
TLDR
There are suggested advantages of more rapid rates of advancing feedings in premature low-birth-weight infants (shorter time to regain birth weight and shorter time to achieve full feedings) and the effect on length of hospital stay remains unclear.
Enteral feeding regimens and necrotising enterocolitis in preterm infants: a multicentre case–control study
TLDR
The data suggest that the duration of trophic feeding and rate of advancement of feed volumes may be modifiable risk factors for NEC in preterm infants.
Early enteral feeding and nosocomial sepsis in very low birthweight infants
TLDR
Early enteral feeding was associated with a reduced risk of NS but no change in the risk of NEC in VLBW infants, and these findings support the use of earlyEnteral feeding in this high risk population, but this needs to be confirmed in a large randomised controlled trial.
Early versus delayed initiation of progressive enteral feedings for parenterally fed low birth weight or preterm infants.
TLDR
Early feedings had no significant effect on weight gain, necrotizing enterocolitis, mortality, or age at discharge, although important effects cannot be excluded with the small number of patients studied.
Enteral antibiotics for preventing necrotizing enterocolitis in low birthweight or preterm infants.
TLDR
Evidence suggests that oral antibiotics reduce the incidence of NEC in low birth weight infants, however concerns about adverse outcomes persist, particularly related to the development of resistant bacteria.
Arginine supplementation prevents necrotizing enterocolitis in the premature infant.
TLDR
Arginine supplementation in premature infants reduces the incidence of all stages of necrotizing enterocolitis and no significant differences in maternal and neonatal demographics, nutrient intake, plasma ammonia and total and essential amino acid concentrations were present between the two groups.
Preventing necrotizing enterocolitis in neonates.
TLDR
This cautions approach to feeding has been applied to selected infants whose condition during labor and delivery or whose neonatal problems indicate that they are at risk ofecrotizing enterocolitis.
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