Entecavir: A New Nucleoside Analog for the Treatment of Chronic Hepatitis B Infection

@article{Sims2006EntecavirAN,
  title={Entecavir: A New Nucleoside Analog for the Treatment of Chronic Hepatitis B Infection},
  author={Keri A. Sims and Abigail M. Woodland},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
  year={2006},
  volume={26}
}
  • Keri A. SimsA. Woodland
  • Published 1 December 2006
  • Medicine, Biology
  • Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Background. Chronic hepatitis B infection carries considerable risk for the development of cirrhosis and hepatocellular carcinoma. Treatment options are increasing but are limited to interferon alfa‐2b, pegylated interferon alfa‐2a, lamivudine, adefovir dipivoxil, and entecavir. Entecavir, a nucleoside analog, is the newest oral antiviral approved in the United States for treatment of chronic hepatitis B. 

A Combination anti-HBV regimen using lamivudine and other agents in treatment of resistant chronic hepatitis B

The study concluded that the clinical benefit is apparent after a combination regimen using Lamivudine + Entecavir + Adefovir + Dipivoxil rather than  a combination  regimen  used to treat resistant hepatitis B, and recommended Optimal management of chronic hepatitis B.

Efavirenz in combination with n-acetyl cysteine shows improved outcome in treatment of hepatitis B

This study provides useful evidence that co-administration of N-acetyl cysteine with efavirenz protects the toxic effect of efvirenz, in patients with hepatitis B infection.

Nucleos(t)ide analogues for the treatment of chronic hepatitis B: a systematic review with network meta-analysis

The nucleos(t)ide analogues are all effective for HBeAg seroconversion, H beAg loss, undetectable HBV DNA, and most are effective for ALT normalization in adults with CHB.

The HBV drug entecavir - effects on HIV-1 replication and resistance.

Caution is needed with the use of entecavir in persons with HIV-1 and HBV coinfection who are not receiving fully suppressive antiretroviral regimens, and in vitro experiments showed that M184V confers resistance to entecvir.

Evaluation of 48-week response of treatment-naive chronic hepatitis B patients to 0.5 mg/day entecavir.

The 48-week entecavir treatment at a dose of 0.5 mg/day was shown to be effective both for HBeAg-positive and negative patients, and antiHBe seroconversion was seen in 2 of 91 patients, but the loss of HBsAg was never observed.

Clinical and Virological Response to Entecavir in HBV-Related Chronic Hepatitis or Cirrhosis: Data from the Clinical Practice in a Single-Centre Cohort

Entecavir represents an excellent therapy in patients with HBV-related liver disease and particularly with cirrhosis where it showed a good profile of tolerability, higher efficacy and an earlier virological response.

Antiviral Drugs for Viruses Other Than Human Immunodeficiency Virus

An overview of clinically available antiviral drugs for the primary care physician is provided, with a special focus on pharmacology, clinical uses, and adverse effects.

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