Entamoeba histolytica thioredoxin reductase: molecular and functional characterization of its atypical properties.

@article{Arias2012EntamoebaHT,
  title={Entamoeba histolytica thioredoxin reductase: molecular and functional characterization of its atypical properties.},
  author={Diego G. Arias and Erika L Regner and Alberto A. Iglesias and Sergio Adri{\'a}n Guerrero},
  journal={Biochimica et biophysica acta},
  year={2012},
  volume={1820 12},
  pages={1859-66}
}
BACKGROUND Entamoeba histolytica, an intestinal protozoan that is the causative agent of amoebiasis, is exposed to elevated amounts of highly toxic reactive oxygen and nitrogen species during tissue invasion. Thioredoxin reductase catalyzes the reversible transfer of reducing equivalents between NADPH and thioredoxin, a small protein that plays key metabolic functions in maintaining the intracellular redox balance. METHODS The present work deals with in vitro steady state kinetic studies… CONTINUE READING
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