Entamoeba histolytica cysteine proteinases disrupt the polymeric structure of colonic mucin and alter its protective function.

@article{Moncada2003EntamoebaHC,
  title={Entamoeba histolytica cysteine proteinases disrupt the polymeric structure of colonic mucin and alter its protective function.},
  author={Darcy M Moncada and Kathy Keller and Kris Chadee},
  journal={Infection and immunity},
  year={2003},
  volume={71 2},
  pages={838-44}
}
The adherent mucous gel layer lining the colonic epithelium is the first line of host defense against invasive pathogens, such as Entamoeba histolytica. The mucous layer prevents the attachment of amoeba to the colonic epithelium by trapping and aiding in the expulsion of the parasite. Disruption of the mucous layer is thought to occur in invasive amebiasis, and the mechanism by which the parasite overcomes this barrier is not known. The aim of this study was to characterize the specific… CONTINUE READING
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Production, structure and function of gastrointestinal mucins, p. 57–79

  • D. Moncada, K. Chadee
  • 2002

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