Entacapone potentiates the long-duration response but does not normalize levodopa-induced molecular changes

@article{Marin2008EntacaponePT,
  title={Entacapone potentiates the long-duration response but does not normalize levodopa-induced molecular changes},
  author={Concepci{\'o} Marin and Esther Aguilar and Guadalupe Mengod and R. Hern{\'a}ndez Cort{\'e}s and Jose A. Obeso},
  journal={Neurobiology of Disease},
  year={2008},
  volume={32},
  pages={340-348}
}
Coadministration of entacapone with levodopa attenuates motor complications in experimental models of Parkinson's disease. The mechanisms underlying entacapone effects are unknown. We investigated the effect of entacapone, on: long-duration response (LDR) to levodopa, levodopa-induced postsynaptic pharmacodynamic mechanisms and molecular changes in hemiparkinsonian rats. 6-Hydroxydopamine-unilaterally lesioned rats were treated with levodopa (25 mg/kg)+vehicle; levodopa+entacapone (30 mg/kg) or… CONTINUE READING
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